In Vitro ADME
Tailored In Vitro ADME Assays for Drug Discovery and Development
We offer a comprehensive range of in vitro ADME assays, from early discovery screens to definitive development studies. Our services include rapid generic automated screens and bespoke assays designed and validated to meet clients' needs.
Key Services:
- Comprehensive in vitro ADME assays from early discovery to development
- Tailored assay design and validation to meet client needs
- Metabolic stability and liability assessments across multiple species
- Binding studies to plasma proteins, tissues, and microsomes (equilibrium dialysis/ultracentrifugation/ultrafiltration)
- Blood:plasma partitioning and reaction phenotyping
- Inhibition studies of P450s/UGTs
- Permeability and absorption studies using Caco-2 and MDCK cell lines
- Identification of reactive metabolites and evaluation of physicochemical properties
Comprehensive, customized in vitro assays to evaluate drug metabolism, stability, and absorption properties.
Applications: Our services help understand drug behavior and inform chemical design strategies by identifying metabolic vulnerabilities. We support regulatory submissions through comprehensive data generation and facilitate understanding of absorption, distribution, metabolism, and excretion (ADME) profiles for drug candidates.
Instrumentation: We utilize advanced technologies, including:
- AB SCIEX Triple Quad 6500+ for quantitative analysis
- Orbitrap and Q-Tof High-Resolution Mass Spectrometers
- Hamilton Star Liquid Handling Robot for HT-ADME studies